abstract：PURPOSE:The contribution of intestinal bacterial strains (gut microbiota) in human metabolism and obesity is being increasingly recognized. The goal of this article was to provide a commentary on the clinical usefulness of these data. METHODS:We performed a review of the currently available articles on PubMed. FINDIN...

journal_title：Clinical therapeutics

authors： van Olden C,Groen AK,Nieuwdorp M

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Public discourse regarding the hepatitis C virus (HCV) drug Sovaldi® (sofosbuvir) has become inflamed, generating much heat but little light concerning the clinical, health economic, and quality-of-life merits of Sovaldi®. The purpose of this article is to provide a factual basis for evaluating the claims regar...

journal_title：Clinical therapeutics

authors： Schiff L

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:The primary purpose of this article was to consider the candidate disruptors of the development of a healthy microbiome in patients with autism. The reported abnormalities in the microbiome of individuals with autism are discussed. METHODS:This selected review used data from published articles related to the a...

journal_title：Clinical therapeutics

authors： Buie T

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Interferon injectables and glatiramer acetate have served as the primary disease-modifying treatments for multiple sclerosis (MS) since their introduction in the 1990s and are first-line treatments for relapsing-remitting forms of MS (RRMS). Many new drug therapies were launched since early 2010, expanding the ...

journal_title：Clinical therapeutics

authors： English C,Aloi JJ

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Each year in France, varicella and zoster affect large numbers of children and adults, resulting in medical visits, hospitalizations for varicella- and zoster-related complications, and societal costs. Disease prevention by varicella vaccination is feasible, wherein a plausible option involves replacing the com...

journal_title：Clinical therapeutics

authors： Littlewood KJ,Ouwens MJ,Sauboin C,Tehard B,Alain S,Denis F

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:A combination of clopidogrel and aspirin is the standard treatment for patients with acute coronary syndrome and those undergoing percutaneous coronary intervention. Two novel antiplatelet agents, ticagrelor and prasugrel, have been shown to rapidly and more effectively inhibit the P2Y12 receptor compared with ...

journal_title：Clinical therapeutics

authors： Jeon HS,Kim MJ,Choi HY,Kim YH,Kim EH,Kim AR,Park HJ,Bae KS,Lim HS

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Saliva is a reliable, noninvasive, and cost-effective alternative to biomarkers measured in other biological fluids. Within certain populations, saliva sampling may be difficult because of insufficient saliva flow, which may compromise disease diagnosis or research integrity. Methods to improve flow rates (eg, ...

journal_title：Clinical therapeutics

authors： Peres JC,Rouquette JL,Miočević O,Warner MC,Slowey PD,Shirtcliff EA

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:This Phase 1 pharmacokinetic (PK) comparability study in healthy subjects was performed to compare the PK properties and tolerability of single-dose golimumab 100 mg delivered subcutaneously by an autoinjector device or by a standard needle and syringe that had been used for the subcutaneous (SC) delivery of go...

journal_title：Clinical therapeutics

authors： Xu Z,Marciniak SJ Jr,Frederick B,Kim L,Zhuang Y,Davis HM,Zhou H

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Coadministration of morphine with oral gabapentin has been shown to increase plasma gabapentin concentrations. This study evaluated whether there was any interaction between gabapentin enacarbil (GEn), which is a prodrug of gabapentin, and morphine in terms of pharmacokinetics, pharmacodynamics, safety, and tol...

journal_title：Clinical therapeutics

authors： Chen C,Upward J,Arumugham T,Stier B,Davy M

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Megestrol acetate oral suspension is an appetite stimulant indicated for cachexia. It is available in a conventional formulation and as a nanocrystal dispersion. The aim of this study was to compare the tolerability and pharmacokinetics of these formulations under fed conditions in healthy Korean volunteers. M...

journal_title：Clinical therapeutics

authors： Kim YH,Choi HY,Jin S,Noh YH,Kim MJ,Park HJ,Lim HS,Bang K,Lee SH,Bae KS

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Samidorphan (3-carboxamido-4-hydroxy naltrexone) is a novel opioid receptor antagonist that is currently in clinical development. The oral dose pharmacokinetics, safety, and tolerability of samidorphan were evaluated in 2 double-blind, placebo-controlled, randomized studies in healthy adults. METHODS:The first...

journal_title：Clinical therapeutics

authors： Turncliff R,DiPetrillo L,Silverman B,Ehrich E

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Surgery, radiotherapy, and chemotherapy are the mainstays of cervical cancer treatment. Many patients receive multiple treatment modalities, each with its own long-term effects. Given the high 5-year survival rate for cervical cancer patients, evaluation and improvement of long-term quality of life are essentia...

journal_title：Clinical therapeutics

authors： Pfaendler KS,Wenzel L,Mechanic MB,Penner KR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Antihypertensive drugs are prescribed to patients with chronic kidney disease (CKD) for their cardioprotective and renoprotective effects. Nationally representative information on the use of antihypertensive drugs among CKD patients is limited. The purpose of this study was to assess the utilization patterns of...

journal_title：Clinical therapeutics

authors： Sonawane KB,Qian J,Hansen RA

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The goal of this study was to assess the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on lipid profiles in patients with type 2 diabetes. METHODS:The MEDLINE, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched from inception through October 31, 2013. Randomized controll...

journal_title：Clinical therapeutics

authors： Sun F,Wu S,Wang J,Guo S,Chai S,Yang Z,Li L,Zhang Y,Ji L,Zhan S

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The purpose of this review is to discuss the selection and use of disease- modifying treatments for patients with relapsing forms of multiple sclerosis (MS). METHODS:PubMed was searched (1966-2014) using the terms multiple sclerosis, treatment, interferon, glatiramer acetate, dimethyl fumarate, fingolimod, ter...

journal_title：Clinical therapeutics

authors： Carrithers MD

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Although recent reports suggest an association between saxagliptin and an increased risk of admissions for heart failure, it is not clear whether dipeptidyl peptidase IV (DPP-IV) inhibition contributes to heart failure in high-risk patients. The purpose of this research is to understand heart failure risk among...

journal_title：Clinical therapeutics

authors： Clifton P

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that disproportionately affects women during their childbearing years. Cardiovascular disease is the leading cause of mortality in this patient population at an age when women often have low cardiovascular risk. Hypertension is a ma...

journal_title：Clinical therapeutics

authors： Gilbert EL,Ryan MJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Interruptions in opioid use have the potential to cause pain relapse and withdrawal symptoms. The objectives of this study were to observe patterns of opioid interruption during acute illness in nursing home residents and examine associations between interruptions and pain and withdrawal symptoms. METHODS:Pati...

journal_title：Clinical therapeutics

authors： Redding SE,Liu S,Hung WW,Boockvar KS

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:The genetic polymorphism was one of the major considerations for adjusting doses of warfarin in Thai individuals. As a result, new oral anticoagulants (NOACs) were introduced to achieve therapeutic goals in stroke prevention in atrial fibrillation (SPAF) patients. However, a cost-utility analysis in a populatio...

journal_title：Clinical therapeutics

authors： Jarungsuccess S,Taerakun S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Pitavastatin, a fully synthetic β-hydroxy-β-methylglutaryl-coenzyme A reductase inhibitor, is potent for the treatment of primary hyperlipidemia and mixed dyslipidemia. Recently, the original product and some generic products of pitavastatin calcium have become available in China. However, the intrasubject v...

journal_title：Clinical therapeutics

authors： Huang YH,Li ZQ,Pan GX,Li YF,Liu Y,Sun JX,Gu XF,Li N,Wang BH

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:Long-acting insulin analogues were developed to facilitate consistent glycemic control without excessive hypoglycemia. However, structural modifications of the insulin molecule can alter biological responses and binding characteristics with specific receptors. The aim of this study was to estimate the risk of s...

journal_title：Clinical therapeutics

authors： Lin JC,Shau WY,Lai MS

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:The effect of peripheral arterial disease (PAD) among young and middle-aged adults can be significant, but no previous study has examined the prognosis and the associated health care cost of the disease in this population. We evaluated the clinical and economic burden of PAD in patients from a large claims data...

journal_title：Clinical therapeutics

authors： Hosaka A,Miyata T,Onishi Y,Liao L,Zhang Q

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The real-world clinical effectiveness of exogenous insulin is limited by nonadherence. Various insulin delivery systems have been developed to help improve adherence, with prefilled pens gaining popularity among adult Singaporeans with diabetes. However, adherence to insulin in people with diabetes in Singap...

journal_title：Clinical therapeutics

authors： Cheen HH,Lim SH,Huang MC,Bee YM,Wee HL

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Antimicrobial prophylaxis in select neutropenic patients has reduced fever, infection rates, hospital length of stay, and hospitalization rates. Guidelines from the Infectious Diseases Society of America recommend the consideration of prophylaxis with a fluoroquinolone in patients at high risk for infection ...

journal_title：Clinical therapeutics

authors： Wojenski DJ,Barreto JN,Wolf RC,Tosh PK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:NSAIDs are associated with risks of gastrointestinal (GI) and cardiovascular (CV) toxicities. It has been reported that the risks of GI and CV events are dose related, resulting in guidance explicitly emphasizing the use of NSAIDs at the lowest effective dose for the shortest duration. To understand the pote...

journal_title：Clinical therapeutics

authors： Odom DM,Mladsi DM,Saag KG,Sherif BN,Miles L,Ronquest N,Wang J

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:In many research and clinical settings in which patient-reported outcome (PRO) measures are used, it is often desirable to link scores across disparate measures or to use scores from 1 measure to describe scores on a separate measure. However, PRO measures are scored by using a variety of metrics, making suc...

journal_title：Clinical therapeutics

authors： Edelen MO,Stucky BD,Sherbourne C,Eberhart N,Lara M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Impaired mineral homeostasis affecting calcium, phosphate, and magnesium is a result of parathyroid hormone (PTH) deficiency in hypoparathyroidism. The current standard of treatment with active vitamin D and oral calcium does not control levels of these major minerals. Recombinant full-length human PTH 1-84 ...

journal_title：Clinical therapeutics

authors： Clarke BL,Kay Berg J,Fox J,Cyran JA,Lagast H

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Many patients with type 2 diabetes mellitus (T2DM) also have hypertension, which is commonly treated with thiazide diuretics, including hydrochlorothiazide (HCTZ). Canagliflozin, a sodium glucose cotransporter 2 inhibitor developed for the treatment of T2DM, lowers plasma glucose by inhibiting renal glucose ...

journal_title：Clinical therapeutics

authors： Devineni D,Vaccaro N,Polidori D,Rusch S,Wajs E

更新日期：2014-05-01 00:00:00

abstract：:Nonadherence to recommended pneumococcal conjugate vaccine (PCV) schedules may have implications for protection against pneumococcal disease. In this commentary, we have assessed adherence to the recommended dosing schedules (the completion of the primary PCV and booster series) in different European countries. We fou...

journal_title：Clinical therapeutics

authors： Gervaix A,Ansaldi F,Brito-Avô A,Azzari C,Knuf M,Martinón-Torres F,Tuerlinckx D,Tin Htar MT,Syrogiannopoulos GA

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Spinal muscular atrophy (SMA) is a fatal motor neuron disease of childhood that is caused by mutations in the SMN1 gene. Currently, no effective treatment is available. One possible therapeutic approach is the use of antisense oligos (ASOs) to redirect the splicing of the paralogous gene SMN2, thus increasin...

journal_title：Clinical therapeutics

authors： Nizzardo M,Simone C,Salani S,Ruepp MD,Rizzo F,Ruggieri M,Zanetta C,Brajkovic S,Moulton HM,Müehlemann O,Bresolin N,Comi GP,Corti S

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Apixaban (5 mg BID), dabigatran (available as 150 mg and 110 mg BID in Europe), and rivaroxaban (20 mg once daily) are 3 novel oral anticoagulants (NOACs) currently approved for stroke prevention in patients with atrial fibrillation (AF). OBJECTIVE:The objective of this study was to evaluate the cost-effect...

journal_title：Clinical therapeutics

authors： Lip GY,Kongnakorn T,Phatak H,Kuznik A,Lanitis T,Liu LZ,Iloeje U,Hernandez L,Dorian P

更新日期：2014-02-01 00:00:00

abstract：:This commentary reviews the difficulties in formulating oral products for children. The significance of the fragmentation of the pediatric population in terms of development and ability to ingest different dosage formulations is examined. It is postulated that a flexible formulation, acceptable by all patient groups, ...

journal_title：Clinical therapeutics

authors： Bar-Shalom D

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease caused by mutations in the survival motor neuron gene (SMN1) and the leading genetic cause of infant mortality. Currently, there is no effective treatment other than supportive care. OBJECTIVE:This article provides a general overvi...

journal_title：Clinical therapeutics

authors： Zanetta C,Nizzardo M,Simone C,Monguzzi E,Bresolin N,Comi GP,Corti S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:New targeted therapeutics for metastatic renal cell carcinoma (mRCC) enable an increment in progression-free survival (PFS) ranging from 2 to 6 months. Compared with best supportive care, everolimus demonstrated an additional PFS of 3 months in patients with mRCC whose disease had progressed on sunitinib and...

journal_title：Clinical therapeutics

authors： Mihajlović J,Pechlivanoglou P,Sabo A,Tomić Z,Postma MJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Emergence agitation (EA) after emergence from sevoflurane anesthesia is a common phenomenon in children. The efficacy of prophylactic midazolam or clonidine in preventing EA is controversial. OBJECTIVE:We performed a meta-analysis of clinical trials of the 2 drugs to evaluate their ability to prevent EA in ...

journal_title：Clinical therapeutics

authors： Zhang C,Li J,Zhao D,Wang Y

更新日期：2013-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder, with a rapidly increasing worldwide prevalence. Although no cure for AD has yet been found, substantial progress has been made in our understanding of AD pathogenesis. This progress has led to the development of numerous promising compounds in vario...

journal_title：Clinical therapeutics

authors： Nygaard HB

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Eperisone hydrochloride, a centrally acting muscle relaxant, is a calcium antagonist that causes vasodilation and antispastic actions. Aceclofenac, an anti-inflammatory analgesic and antipyretic drug, has similar efficacy and improved gastrointestinal tolerance compared with other nonsteroidal anti-inflammat...

journal_title：Clinical therapeutics

authors： Kim MJ,Lim HS,Noh YH,Kim YH,Choi HY,Park KM,Kim SE,Bae KS

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Inhaled antibacterial agents are used to manage chronic pulmonary infections in cystic fibrosis (CF) and non-CF bronchiectasis. However, established nebulized preparations impose a substantial time burden on patients. A dry powder formulation of ciprofloxacin for inhalation (ciprofloxacin DPI) has been devel...

journal_title：Clinical therapeutics

authors： Stass H,Weimann B,Nagelschmitz J,Rolinck-Werninghaus C,Staab D

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Flexibility in the recommended dosing time for a statin may improve patient compliance. OBJECTIVE:This study was designed to compare the efficacy and tolerability of morning and evening doses of controlled-release simvastatin in Korean adults with dyslipidemia. It was carried out as a requirement to obtain ...

journal_title：Clinical therapeutics

authors： Kim SH,Kim MK,Seo HS,Hyun MS,Han KR,Cho SW,Kim YK,Hoon Park S

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:LX4211 is a first-in-class dual inhibitor of sodium-dependent glucose cotransporters 1 and 2 (SGLT1 and SGLT2). SGLT1 is the primary transporter for glucose absorption from the gastrointestinal tract, and SGLT2 is the primary transporter for glucose reabsorption in the kidney. SGLT1 inhibition reduces postpr...

journal_title：Clinical therapeutics

authors： Zambrowicz B,Ogbaa I,Frazier K,Banks P,Turnage A,Freiman J,Boehm KA,Ruff D,Powell D,Sands A

更新日期：2013-08-01 00:00:00